Evaluation of therapeutic effects of 125I particles brachytherapy for recurrent bladder cancer
نویسندگان
چکیده
The aim of the present study was to evaluate the clinical value of 125I particles implantation in the treatment of recurrent bladder cancer. The study is a retrospective analysis of 32 patients with recurrent bladder cancer treated between May 2010 and January 2010. Of these, 16 cases (chemotherapy group) received conventional chemotherapy. A total of 16 patients (125I group) received radiotherapy with 125I particles, followed by conventional chemotherapy. By guidance of B ultrasound, 125I radioactive particles were implanted. All 32 patients were relieved after treatment, and the tumors were significantly reduced after 2 months. However, the tumors in the 125I group were significantly smaller than those in the chemotherapy group (P<0.05). The patients were followed-up for 1 year and no recurrence was found. Additionally, no complications occurred. Compared with the chemotherapy group, the tumor volume of the 125I group was significantly reduced (P<0.05). The disease-free survival and 5-year survival rates of the patients in the follow-up showed that the disease-free survival and 5-year survival rates of the patients in 125I group were significantly improved compared to those in the chemotherapy group. Therefore, the results have shown that 125I radioactive particles in the treatment of bladder cancer improve the symptoms of patients with bladder cancer in the short term, and continuously kill residual tumor and prevent recurrence.
منابع مشابه
The Effect of Scattering from Leg Region on Organ Doses in Prostate Brachytherapy for 103Pd, 125I and 131Cs Seeds
Introduction Dose calculation of tumor and surrounding tissues is essential during prostate brachytherapy. Three radioisotopes, namely, 125I, 103Pd, and 131Cs, are extensively used in this method. In this study, we aimed to calculate the received doses by the prostate and critical organs using the aforementioned radioactive seeds and to investigate the effect of scattering contribution for the ...
متن کاملEffects of different carriers for adsorption of I-125 on brachytherapy sources
Background: One of the key techniques for the preparation of 125I seeds is adsorption of 125I onto silver bits coated by palladium (pd). Carriers played an important role in the adsorption of 125I on palladium. KI is used as a carrier for fixing of 125I onto silver wire bits coated with palladium. Materials and Methods: Three procedures KI, KOH, NH4OH were investigated for adsorption of ...
متن کاملCT-guided 125I brachytherapy for locally recurrent nasopharyngeal carcinoma
Purpose: The study evaluated the feasibility, clinical effectiveness, and quality of life of computed tomography (CT)-guided 125I brachytherapy for locally recurrent nasopharyngeal carcinoma (NPC). Methods: We recruited 81 patients diagnosed with locally recurrent NPC after previous radiotherapy with or without chemotherapy. Thirty-nine patients received 125I brachytherapy (group A) and 42 rece...
متن کاملEvaluation of deformable image registration in HDR gynecological brachytherapy
Introduction: In brachytherapy, as in external radiotherapy, image-guidance plays an important role. For GYN treatments it is standard to acquire at least CT images and preferably MR images prior to each treatment and to calculate the dose of the day on each set of images. Then, the dose to the target and to the organs at risk (OAR) is calculated with worst case scenario from I...
متن کاملDosimetry Comparison of Water Phantom and Complete Eye Definition for 125I and 103Pd Brachytherapy Plaques
Introduction: In this paper, by complete definition of human eye containing the various parts and their materials, the difference between this model and a homogeneous water phantom are compared for two ophthalmic plaques using 125I and 103Pd. Material and methods: The simulation of the two phantoms were performed in the MCNP-4C code and by using the geometry of a three-dimensional eye, differen...
متن کامل